A fictionalized account of the life of William F. "Buffalo Bill" Cody. A hunter and Army Scout in the early part of his life, he rescues a US Senator and his beautiful daughter, Louisa Frederici. Cody is portrayed as someone who admires and respects the Indians and is a good friend of Yellow Hand who will eventually become Chief of the Cheyenne. Everyone else, including the military, politicians and businessmen on the other hand hate the Indians and are perfectly prepared to trample on their lands and destroy their buffalo hunting grounds. He's eventually forced to fight the Cheyenne however. He's also met a writer, Ned Buntline, who writes about Cody's exploits and he becomes a sensation when he travels East. His career is not assured however, particularly when he attacks those in positions of authority over their maltreatment of the Native American population. He eventually establishes his wild west show that becomes an international sensation.

Cullen Bohannon, a former soldier and slaveholder, follows the track of a band of Union soldiers, the killers of his wife. This brings him to the middle of one of the biggest projects in US history, the building of the transcontinental railroad. After the war years in the 1860s, this undertaking connected the prospering east with the still wild west.

In the Wild West town of Mudbug, Sheriff Sugar Wolf arrives to confront an over-the-top villain, Big Baby Chips.

A quiet and peaceful community in the Dominion of Canada is shaken up by the arrival of a wounded and stinky gun-toting American cowboy, simply known as The Montana Kid, wanted for the alleged killing of seven men. A subsequent clarification reveals that his real name is Sean Rafferty, and he admits to killing, not seven, but eleven men. Things only get worse after Sean gets in the bad books of the local militia, and with armed bounty hunters hot on his trail, challenges the local unarmed blacksmith, Jack Smith, to a duel - wild west style!

Tate Noble returns to the town of his youth where as a boy his parents were murdered. His childhood friend Samuel, now the sheriff of La Mesa knows who is responsible, and Tate's arrival sparks hostility between Samuel and his father Judge Carter. As the mystery unravels, Tate and Samuel enlist help from an unlikely source, the mob, in order to bring to justice the man ultimately responsible, the evil Harcourt Simms.

Molly, the shy, romance-starved wife of an arrogant frontier sheriff, finds herself drawn to a prisoner in her husband's jail. This prisoner, a handsome young man named Johnny, plays on Molly's sympathy and convinces her to help him escape. Molly then accompanies Johnny on his cross-country flight but soon learns he's simply been using her. Molly makes the best of the situation, however, and by the time the sheriff's posse catches up with them, Molly shows that she's learned how to assert herself.